Kambo Peptides

The main families of peptides identified in the Kambo secretion thus far include:

Phyllomedusin

Produces contraction at the smooth muscle level and increases secretions of the entire gastrointestinal tract such as the salivary glands, stomach, small and large intestine, pancreas and gallbladder.

These peptides work to induce the deep purge that takes place in a Kambo session.

Phyllokinin & Phyllomedusins

Both are potent vasodilators, increasing the permeability of the blood-brain barrier for their own access, as well as for that of other active peptides. They also have antimicrobial and antifungal properties.

Caeruleins & Sauvagines

These peptides have chains of 40 amino acids with myotropic properties on the smooth muscles, producing a contraction of the colon and urinary bladder. They produce a drop in blood pressure accompanied by tachycardia. They stimulate the adrenal cortex and pituitary gland, contributing to greater sensory perception and increased resistance. Both peptides possess a great analgesic power, contributing to the increase of physical strength, the capacity to confront physical pain, stress, disease, and diminish the symptoms of fatigue. In the medical field, this family of peptides contributes to improved digestion and has analgesic properties against pain in the renal colic, pain due to peripheral vascular insufficiency and tumor pain.

Dermorphin & Deltorphin

Small peptides composed of 7 amino acids. They are selective agonists of the opiate receptors, 4000 times more potent than morphine and 40 times more potent than the endogenous endorphins.

Adenoregulins

These work on the human body through the adenosine receptors, a fundamental component throughout all human cellular fuel. These receptors may offer a target for the treatment of depression, stroke, and cognitive diseases such as Alzheimer’s Disease and Parkinson’s.

Dermaseptins

These peptides are part of a broad spectrum of antimicrobial peptides involved in the frog’s defence against microbial invasion. These are the first vertebrate peptides that show lethal effects against filamentous fungi responsible for severe opportunistic infections which accompany immunodeficiency syndrome and the use of immunosuppressive agents. They also show lethal effects against a broad spectrum of bacteria, fungi, yeasts, and protozoa.

Several years of research at the University of Paris have shown that peptides Dermaseptin B2 and B3 are effective in killing certain types of cancer cells. A researcher at Queens University in Belfast won a prestigious award for his ground-breaking work with cancer and Kambo. It’s action mechanism is produced by inhibiting the angiogenesis of tumor cells with selective cytotoxicity for these cells.

Bradykinins

These peptides have similar properties and structure to human bradykinin.

They are hypotensive, and due to producing vasodilation, they support contraction of the non-vascular smooth muscle,

increase vascular permeability, and are related to the mechanism of inflammatory pain.

Bombesins

These peptides stimulate the secretion of hydrochloric acid by acting on the G cells of the stomach. They also increase pancreatic secretion, intestinal myoelectric activity, and smooth muscle contractility.

Ceruleans

They stimulate gastric, bile, and pancreatic secretions, and certain smooth muscles. They could be used in the paralytic ileus and as a diagnostic medium in pancreatic dysfunction.

Tryptophilins 

These are neuropeptides consisting of 4-14 amino acids, which are opening up new perspectives on how the human brain works.